MUC16 - mucin 16, cell surface associated Gene

Also Known as CA125

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 94025

About MUC16

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,848,844-9,010,437 (from NCBI)

This gene has 5 transcripts (splice variants), 85 orthologues and is associated with 139 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a protein that is a member of the Mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered Mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

MUC16 Products (4)

mRNA	Protein	Name
NM_001401501.2	NP_001388430.1	mucin-16 isoform 2 precursor
NM_001414686.1	NP_001401615.1	mucin-16 isoform 1 precursor
NM_001414687.1	NP_001401616.1	mucin-16 isoform 3
NM_024690.2	NP_078966.2	mucin-16 isoform 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14676194	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12766047	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MUC16 Protein Structure

SEA

0
2300
4600
6900
9200
11500
13800
14507 a.a.

Protein Preferred Names	Protein Names
mucin-16	CA125 ovarian cancer antigen

Recombinant MUC16 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7696	CA125 Protein, Human (HEK293, His)	Q8WXI7 (G12660-M12923)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72347	CA125 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q8WXI7 (G12660-M12923)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78178	CA125 Protein, Human (Biotinylated, HEK293, His-Avi)	Q8WXI7 (G12660-M12923)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78493	CA125 Protein, Human (HEK293, His-Avi)	Q8WXI7 (G12660-M12923)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700960	CA125 Protein, Human (Biotinylated, 685a.a, HEK293, His-Avi)	Q8WXI7 (D12783-S13467)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700961	CA125 Protein, Human (685a.a, HEK293, His)	Q8WXI7 (D12783-S13467)	≥ 95%, as determined by reducing SDS-PAGE.

MUC16 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80991	MUC16 Antibody (YA3530)	WB, IHC-P	Human
HY-P81044	MUC16 Antibody (YA890)	WB, ICC/IF, IHC-P, FC	Human
HY-P84692	MUC16 Antibody (YA4389)	IHC-P, FC, ELISA	Human
HY-P84692A	MUC16 Antibody (YA4389)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86006	MUC16 Antibody (YA5698)	IHC-P, ICC/IF, ELISA	Human
HY-P86753	MUC16 Antibody (YA6445)	WB, ICC/IF, FC, IHC-P, IHC-F, IF-Tissue	Human
HY-P86753A	MUC16 Antibody (YA6445)(PBS only)	WB, ICC/IF, FC, IHC-P, IHC-F, IF-Tissue	Human

Related Diseases

Diseases	Alias
Clear Cell Adenocarcinoma	Mesonephroma Water-Clear Cell Adenocarcinoma Adenocarcinoma, Clear Cell Malignant Mesonephroma Mesonephroid Clear Cell Carcinoma Mesonephroma, Malignant Water-Clear Cell Carcinoma Wolffian Duct Neoplasm Adenocarcinoma Clear Cell Mesonephric Tumor
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Ovarian Cyst	Ovarian Cysts
Cystadenocarcinoma
Papillary Adenocarcinoma	Infiltrating And Papillary Adenocarcinoma Infiltrating Papillary Adenocarcinoma Adenocarcinoma Papillary Adenocarcinoma, Papillary
Endodermal Sinus Tumor	Yolk Sac Tumor Endodermal Sinus Tumour Hepatoid Yolk Sac Tumour Infantile Embryonal Carcinoma Yolk Sac Neoplasm Yolk Sac Tumour
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Ovarian Cystadenoma	Cystoma Serosum Simplex Simple Cystoma Of Ovary Simple Cystoma Of The Ovary
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Pericardial Effusion	Noninflammatory Pericardial Effusion Pericardium Effusion
Tuberculous Peritonitis	Peritonitis, Tuberculous Peritonitis Tuberculous
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Keratoconjunctivitis
Lymphatic Malformation 5	Meige Syndrome Meige Disease Meige Lymphedema Lymphedema Praecox Lymphedema, Late-Onset Late-Onset Lymphedema LMPH2 Meigs Syndrome LMPHM5 Lymphedema, Hereditary, Ii, Formerly Lmph2, Formerly Hereditary Lymphedema Ii Demons-Meigs Syndrome Hereditary Lymphedema Type Ii Lymphedema, Hereditary, 2 Lymphedema, Hereditary, Ii Meige'S Disease
Fibroma
Adenofibroma
Ovarian Disease	Ovarian Dysfunction Ovarian Diseases Ovarian Disorders Disorder Of Endocrine Ovary
Corpus Luteum Cyst	Cystic Corpus Luteum Luteal Cystic Ovary Disease Lutein Cyst Granulosa Lutein Cyst
Obstructive Jaundice	Jaundice, Obstructive Cholestatic Jaundice Cholestatic Jaundice Syndrome Obstructive Hyperbilirubinemia Jaundice Obstructive Jaundice Cholestatic
Mucinous Cystadenocarcinoma	Cystadenocarcinoma, Mucinous Pseudomucinous Cystadenocarcinoma Cystadenocarcinoma Mucinous
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Pseudomyxoma Peritonei	Adenomucinosis Gelatinous Ascites Pmp Mucinous Ascites Syndrome Of Pseudomyxoma Peritonei
Filamentary Keratitis
Ovarian Serous Cystadenocarcinoma	Serous Cystadenoma Cystadenoma Serous Cystadenoma, Serous
Bronchogenic Cyst
Adenomyosis	Endometriosis Of Uterus Endometriosis Interna Endometriosis Of Myometrium Endometriosis, Myometrium Uterine Adenomyosis Adenomyosis Uteri Internal Endometriosis
Ovarian Brenner Tumor	Benign Ovarian Brenner Tumor Brenner Tumor Benign Ovarian Brenner Tumour Ovarian Brenner Tumour Brenner Tumor Of Ovary Benign Brenner Tumor
Leiomyosarcoma	Leiomyosarcomas
Cystadenoma	Cystoma Craniopharyngioma
Pleurisy
Struma Ovarii
Myxedema
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Punctate Epithelial Keratoconjunctivitis	Punctate Keratitis Thygeson Superficial Punctate Keratitis Thygeson'S Superficial Punctate Keratitis Thygeson Superficial Punctate Keratopathy Punctate Epithelial Keratitis
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Opisthorchiasis	Infection By Opisthorchis Infection Due To Opisthorchis Infection Due To Cat Liver Fluke Infection By Cat Liver Fluke Opisthorchiosis Cat Liver Fluke Fever Cat Liver Fluke Disease Opisthorchis Infestation Cat Liver Fluke Infestation
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Colorectal Cancer, Hereditary Nonpolyposis, Type 8	HNPCC8 Hereditary Nonpolyposis Colorectal Cancer Type 8 Hereditary Non-Polyposis Colorectal Cancer 8 Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Polycystic Liver Disease 1 PCLD1 Cyst Liver Disease, Polycystic, Type 1 Polycystic Liver Disease
Cervical Adenocarcinoma	Adenocarcinoma Cervix Uteri Adenocarcinoma Of Cervix Adenocarcinoma Of The Uterine Cervix Adenocarcinoma Of The Cervix Uteri
Shipyard Eye	Epidemic Keratoconjunctivitis Ekc
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Papillary Cystadenocarcinoma	Cystadenocarcinoma, Papillary
Conjunctivochalasis
Cicatricial Pemphigoid	Mucous Membrane Pemphigoid Ocular Pemphigoid Benign Mucous Membrane Pemphigoid Benign Mucous Membrane Pemphigoid With Ocular Involvement Benign Mucosal Pemphigoid Pemphigoid, Benign Mucous Membrane Cicatricial Pemphigoid With Ocular Involvement Ocular Pemphigus Cicatricial Pemphigoid Disease Mucosal Pemphigoid Mucosynechial Pemphigoid Pemphigoid Cicatricial Cicatricial Pemphigoid Involving The Eye Ocular Cicatricial Pemphigoid
Lacrimal Apparatus Disease	Lacrimal Apparatus Diseases
Dry Eye Syndrome	Dry Eye Syndromes Dry Eye Disease Tear Film Insufficiency Xerophthalmia
Blepharitis
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Fallopian Tube Endometrioid Adenocarcinoma	Endometrioid Carcinoma Of The Fallopian Tube Fallopian Tube Endometrioid Cancer Fallopian Tube Endometrioid Neoplasm Fallopian Tube Endometrioid Tumor
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Ovary Adenocarcinoma	Ovarian Adenocarcinoma Adenocarcinoma Of The Ovary Ovarian Adenoacanthoma Adenocarcinoma Of Ovary
Ovarian Cystadenocarcinoma	Cystadenocarcinoma Of Ovary Cystadenocarcinoma Of The Ovary
Malignant Ovarian Surface Epithelial-Stromal Neoplasm	Malignant Ovarian Surface Epithelial-Stromal Tumor
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99539	Ubamatamab		≥99.0%	Phase 2
HY-P99593	Sofituzumab vedotin		98.97%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08835	MUC16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18071	Muc16 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24546	Muc16 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99237	Sofituzumab	Inhibitor	95.86%	Unkown
HY-P991166	Ubletamig	Inhibitor	/	Unkown
HY-P992270	Anti-MUC16 Antibody (MMUC3333A)		/	Unkown
HY-P990830	Anti-MUC16 Antibody (VK8)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MUC16	RGD	RGD:1308422
Mus musculus	MUC16	MGD	MGI:1920982